Effects of Glutamate on the Reflex of Circulatory System under Hypoxic Condition

In this study, we investigated the effects of glutamate, the neurontransmitter, on the reflex mechanism of circulatory system to hypoxia. Male Wistar rats were subjeted to hypoxic condition (10% O2 in N2). Glutamate were injected to cerebrospinal fluid of rats using Hamilton injector connecting with stereotaxic system with a constant velocity of 1 µl/s for 5 mins. Our results showed that glutamate reduced or suppressed the responses of circulatory system under hypoxic condition. A decrease in mean arterial pressure (55 - 66%) and an increase in heart rate (6 - 12%) in comparison with normal levels were observed. These data suggested that glutamate in cerebrospinal fluid may be a regulatory factor of circulatory system in response to hypoxic condition...

Link: http://repository.vnu.edu.vn/handle/VNU_123/61549

Nhận xét

Bài đăng phổ biến từ blog này